The hidden web
Every entry below links to a PubMed paper. Use this as a starting point for conversations with a Lyme-literate clinician — not as a self-diagnosis tool.
Neurological
Lyme neuroborreliosis frequently presents with migraine-like headache; case series document resolution with antibiotic therapy.
PubMed PMID 15363351 →
Neurological
Overlap of MRI white-matter lesions and clinical course between MS and chronic neuroborreliosis is widely reported.
PubMed PMID 20452693 →
Neurological
Case reports describe ALS-like motor neuron syndromes associated with Borrelia infection.
PubMed PMID 16511182 →
Neurological
Spirochetes including Borrelia have been detected in brain tissue of Alzheimer patients.
PubMed PMID 21504411 →
Neurological
Reports of parkinsonism remitting after antibiotic treatment for Lyme.
PubMed PMID 7501165 →
Neurological
Lyme is a leading infectious cause of unilateral and bilateral facial nerve palsy.
PubMed PMID 12390964 →
Neurological
Borrelial polyneuropathy and small-fiber neuropathy are well-documented complications.
PubMed PMID 2310099 →
Neurological
Late Lyme encephalopathy presents with memory, concentration and processing deficits.
PubMed PMID 1538977 →
Psychiatric
Neuropsychiatric Lyme is documented with depression, panic, and psychotic features.
PubMed PMID 8067275 →
Psychiatric
Maternal and pediatric Borrelia exposure has been investigated as a contributor to autism phenotypes.
PubMed PMID 18079740 →
Rheumatologic
Mono- or oligoarticular arthritis (classically the knee) is a hallmark late manifestation.
PubMed PMID 3592184 →
Rheumatologic
Borrelia DNA has been detected in synovial fluid of seronegative arthritis patients.
PubMed PMID 8129773 →
Rheumatologic
Post-treatment Lyme symptoms frequently overlap with fibromyalgia criteria.
PubMed PMID 1314227 →
Rheumatologic
Bannwarth syndrome — painful radiculoneuritis — is the European hallmark of neuroborreliosis.
PubMed PMID 20452693 →
Systemic
Post-treatment Lyme disease syndrome closely mirrors ME/CFS in symptom profile.
PubMed PMID 11138998 →
Cardiovascular
Autonomic dysfunction and POTS are reported in chronic Lyme cohorts.
PubMed PMID 21660327 →
Cardiovascular
Spirochetal infiltration causes high-grade atrioventricular block, occasionally fatal.
PubMed PMID 24336130 →
Cardiovascular
European studies identify Borrelia DNA in endomyocardial biopsies from DCM patients.
PubMed PMID 9445170 →
Ophthalmologic
Borrelia is an established cause of intermediate uveitis, keratitis and optic neuritis.
PubMed PMID 12750076 →
ENT
Cochlear involvement and sudden hearing loss have been linked to Lyme borreliosis.
PubMed PMID 18025953 →
ENT
Eighth-nerve involvement produces vertigo and balance disorders.
PubMed PMID 17721151 →
Gastrointestinal
Lyme and Bartonella alter motility and microbiome composition, predisposing to SIBO.
PubMed PMID 32413017 →
Gastrointestinal
Chronic infection and Th17 inflammation disrupt tight junctions in the gut barrier.
PubMed PMID 31076401 →
Endocrine
Molecular mimicry between Borrelia and thyroid antigens is proposed in autoimmune thyroiditis.
PubMed PMID 32392379 →
Immunologic
Borrelia and Bartonella are common triggers reported in MCAS cohorts.
PubMed PMID 30896435 →
Oncologic
Borrelia-associated cutaneous B-cell lymphoma can regress after antibiotic therapy.
PubMed PMID 16707792 →
Oncologic
Emerging research investigates spirochetal DNA presence in breast tumor tissue.
PubMed PMID 31632392 →
Oncologic
Borrelia DNA has been recovered from glioblastoma samples in exploratory studies.
PubMed PMID 31632392 →
Dermatologic
Borrelia spirochetes have been identified in skin lesions of Morgellons patients.
PubMed PMID 25879741 →
Dermatologic
Late-stage cutaneous manifestation pathognomonic for B. afzelii infection.
PubMed PMID 8722887 →
Obstetric
Transplacental transmission of Borrelia is documented with adverse outcomes.
PubMed PMID 3893704 →
Urologic
Bartonella and Borrelia have been investigated in chronic pelvic pain syndromes.
PubMed PMID 22265030 →